The TBL1Y Polyclonal Antibody (PACO17368) is a valuable tool for researchers studying TBL1Y, a protein involved in gene regulation and cell signaling pathways. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to TBL1Y, this antibody enables precise detection and analysis of the protein in various cell types, making it ideal for investigations in molecular biology and cancer research.TBL1Y, a component of the NCoR/SMRT corepressor complex, plays a crucial role in controlling gene expression and cell differentiation processes.
Its dysregulation has been linked to the development of various diseases, including cancer and neurological disorders. Studying the function of TBL1Y is essential for unraveling its contributions to these pathologies and developing targeted therapeutic interventions.By using the TBL1Y Polyclonal Antibody (PACO17368), researchers can gain insight into the molecular mechanisms underlying TBL1Y-mediated pathways and potentially identify new targets for drug development. This antibody is a valuable resource for advancing our understanding of TBL1Y biology and its implications in health and disease.
Antibody Name:
TBL1Y Antibody (PACO17368)
Antibody SKU:
PACO17368
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human TBL1Y
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17368(TBL1Y Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO17368(TBL1Y Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein.
Synonyms:
transducin (beta)-like 1, Y-linked
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
