The TENM3 Polyclonal Antibody (PAC018963) is a valuable tool for researchers studying TENM3, a critical protein involved in various cellular processes. This antibody is produced in rabbits and has high reactivity with human samples, making it suitable for use in Western blot applications. By binding to the TENM3 protein, this antibody enables the detection and analysis of TENM3 in different cell types, making it an ideal choice for studies in developmental biology and neurobiology.TENM3 is a transmembrane protein that plays a crucial role in cell adhesion, migration, and axon guidance during development.
Its involvement in these processes highlights its importance in various physiological functions, including nervous system development and tissue regeneration. Research on TENM3 can provide insights into neurodevelopmental disorders, neurological diseases, and cancer progression, making the TENM3 Polyclonal Antibody a valuable tool in advancing scientific knowledge in these areas.
Antibody Name:
TENM3 Antibody (PACO18963)
Antibody SKU:
PACO18963
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:3000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TENM3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18963(TENM3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO18963(TENM3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This protein involved in neural development, regulating the establishment of proper connectivity within the nervous system. It promotes axon guidance and homophilic cell adhesion. And it plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.
Synonyms:
teneurin transmembrane protein 3
UniProt Protein Function:
ODZ3: May function as a cellular signal transducer. Belongs to the tenascin family. Teneurin subfamily.Protein type: Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 4q35.1Cellular Component: axon; integral to membrane; membraneMolecular Function: protein heterodimerization activity; protein homodimerization activityBiological Process: camera-type eye morphogenesis; homophilic cell adhesion; signal transductionDisease: Microphthalmia, Isolated, With Coloboma 9
UniProt Protein Details:
NCBI Summary:
This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]
