Description
TFEC Antibody (PACO12716)
The TFEC Polyclonal Antibody (PAC012716) is a valuable tool for researchers studying TFEC, a transcription factor known for its role in regulating gene expression and cellular processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards TFEC in human samples, making it an ideal choice for Western blot applications.TFEC, also known as transcription factor EC, is involved in various biological functions, including cell growth, differentiation, and survival. Its dysregulation has been linked to diseases such as cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions.
By targeting TFEC with this antibody, researchers can gain valuable insights into its function and potential as a therapeutic target for various diseases.Overall, the TFEC Polyclonal Antibody is a reliable tool for researchers interested in studying TFEC and its involvement in cellular processes and disease mechanisms. Its high reactivity and specificity make it a valuable asset for studies in molecular biology, cancer research, and more.
| Antibody Name: | TFEC Antibody (PACO12716) |
| Antibody SKU: | PACO12716 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TFEC |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | transcription factor EC;TFEC;TCFEC;TFECL;bHLHe34 ; |
| UniProt Protein Function: | TFEC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence. Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer. Binds DNA in a homo- or heterodimeric form. Belongs to the MiT/TFE family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7q31.2 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein dimerization activity; DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O14948 |
| NCBI GenInfo Identifier: | 74705481 |
| NCBI Gene ID: | 22797 |
| NCBI Accession: | O14948.1 |
| UniProt Secondary Accession: | O14948,Q5H9U8, Q709A4, Q8N6J9, B2R8X5, |
| UniProt Related Accession: | O14948 |
| Molecular Weight: | 347 |
| NCBI Full Name: | Transcription factor EC |
| NCBI Synonym Full Names: | transcription factor EC |
| NCBI Official Symbol: | TFECÂ Â |
| NCBI Official Synonym Symbols: | TCFEC; TFE-C; TFECL; TFEC-L; bHLHe34; hTFEC-LÂ Â |
| NCBI Protein Information: | transcription factor EC; class E basic helix-loop-helix protein 34 |
| UniProt Protein Name: | Transcription factor EC |
| UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 34; bHLHe34; Transcription factor EC-like; hTFEC-L |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFECÂ Â |
| UniProt Entry Name: | TFEC_HUMAN |
