The TFF1 Polyclonal Antibody (CAB13358) is a valuable tool for researchers studying Trefoil Factor 1 (TFF1), a protein involved in mucosal protection and repair in the gastrointestinal tract. This polyclonal antibody, generated in rabbits, has high specificity and sensitivity for detecting TFF1 in human samples, making it ideal for use in applications such as immunohistochemistry and ELISA.TFF1 is known for its role in maintaining the integrity of the mucosal barrier in the stomach and intestines, as well as promoting cell migration and proliferation during tissue repair.
Dysregulation of TFF1 expression has been implicated in various gastrointestinal disorders, including inflammatory bowel disease and gastric cancer. By using the TFF1 Polyclonal Antibody, researchers can investigate the function and expression of TFF1 in different cell types and tissues, leading to a better understanding of its impact on gastrointestinal health and disease.
Product Name:
TFF1 Rabbit Polyclonal Antibody
SKU:
CAB13358
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-84 of human TFF1/pS2 (NP_003216.1).
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Purification Method:
Affinity purification
Gene ID:
7031
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TFF1/pS2 antibody (CAB13358) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
