The TGDS Polyclonal Antibody (PACO12723) is a valuable tool for researchers studying TGDS, a key enzyme involved in the biosynthesis of glycosaminoglycans. This antibody, generated in rabbits, is highly specific and reacts with samples from various species, including human, mouse, and rat. Validated for use in applications such as immunohistochemistry and ELISA, this antibody allows for the detection and quantification of TGDS in different cellular contexts.TGDS, or Tumor Necrosis Factor-inducible Gene 6 Protein, is known for its role in the synthesis of dermatan sulfate, an important component of the extracellular matrix.
Dysregulation of TGDS activity has been linked to various diseases, including cancer, cardiovascular disorders, and connective tissue disorders. By studying the expression and function of TGDS using this antibody, researchers can gain insights into the molecular mechanisms underlying these pathologies and potentially identify new therapeutic targets.
TGDS: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily.Protein type: EC 4.2.1.46; LyaseChromosomal Location of Human Ortholog: 13q32.1Molecular Function: coenzyme binding; dTDP-glucose 4,6-dehydratase activityBiological Process: nucleotide-sugar metabolic processDisease: Catel-manzke Syndrome
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
