The THNSL2 Antibody (PAC012740) is a polyclonal antibody designed for research involving THNSL2, a crucial enzyme involved in tRNA 5'-end processing. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications, enabling the detection and analysis of THNSL2 protein in various cell types.THNSL2 plays a vital role in RNA biology, specifically in RNA metabolism and processing. It is essential for maintaining proper tRNA function and stability, making it a key target for studies in molecular biology and biochemistry.
Understanding the function and regulation of THNSL2 is essential for advancing research in genetic diseases, cancer, and other conditions related to RNA processing abnormalities.Overall, the THNSL2 Antibody (PAC012740) is a valuable tool for researchers seeking to delve deeper into the molecular mechanisms involving THNSL2 and its implications in various biological processes and disease states.
threonine synthase-like 2 (S. cerevisiae);THNSL2;FLJ10916;THS2;TSH2 ;
UniProt Protein Function:
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate ().
UniProt Protein Details:
NCBI Summary:
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
