The Timeless Polyclonal Antibody (CAB4261) is a valuable tool for researchers studying the Timeless protein, a key player in the regulation of circadian rhythms and DNA damage response. This antibody is raised in rabbits and has high reactivity with human samples, making it suitable for a variety of research applications.The Timeless Polyclonal Antibody is validated for use in Western blotting, immunofluorescence, and immunoprecipitation assays, providing researchers with flexibility in their experimental approaches. By specifically binding to the Timeless protein, this antibody allows for precise detection and analysis in various cell types, making it an essential component for studies in molecular biology and chronobiology.
The Timeless protein is known for its essential role in maintaining the integrity of the genome and coordinating cellular processes in response to environmental cues. Research on Timeless has implications for understanding biological rhythms, cell cycle regulation, and DNA repair mechanisms, with potential applications in the fields of cancer biology, neuroscience, and aging research.Overall, the Timeless Polyclonal Antibody is a valuable resource for researchers looking to unravel the complexities of circadian biology and DNA repair pathways, providing insights into fundamental biological processes with broad relevance in health and disease.
Product Name:
TIMELESS Rabbit Polyclonal Antibody
SKU:
CAB4261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 969-1208 of human TIMELESS (NP_003911.2).
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders.
Purification Method:
Affinity purification
Gene ID:
8914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from BxPC-3 cells, using TIMELESS Rabbit pAb (CAB4261) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
