The TIN2/TINF2 Antibody (CAB6769) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the TINF2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in aging, cancer, and genetic disorders.TINF2, a component of the shelterin complex, plays a crucial role in protecting chromosome ends and preserving genomic integrity.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
TIN2/TINF2 Antibody
SKU:
CAB6769
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
TIN2, DKCA3, TIN2/TINF2
Positive Sample:
MCF7, HepG2, Mouse skeletal muscle, Mouse heart
Cellular Localization:
Chromosome, Nucleus, Nucleus Matrix, Telomere.
Calculated MW:
50kDa
Observed MW:
40-45kDa
This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.
Purification Method
Affinity purification
Gene ID
26277
RRID
AB_2767352
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using TIN2/TINF2 Rabbit pAb (CAB6769) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
