The TLR7 Polyclonal Antibody (CAB0991) is a valuable tool for researchers investigating Toll-like receptor 7 (TLR7) signaling pathways in the immune system. TLR7 is a key player in the recognition of viral nucleic acids and the initiation of antiviral immune responses. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunohistochemistry.By targeting the TLR7 protein, this antibody enables researchers to study the role of TLR7 in immune response modulation, inflammation, and autoimmune diseases.
It can be used to detect and analyze TLR7 expression in different cell types, providing valuable insights into the function of this important receptor in both normal and pathological conditions.Overall, the TLR7 Polyclonal Antibody (CAB0991) is a reliable tool for studying TLR7 biology and its implications in immune-related research, making it a valuable asset for studies in immunology, infectious diseases, and vaccine development.
Product Name:
TLR7 Rabbit Polyclonal Antibody
SKU:
CAB0991
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-230 of human TLR7 (NP_057646.1).
Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Single-pass type I membrane protein, phagosome.
Calculated MW:
121kDa
Observed MW:
150kDa
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X.
Purification Method:
Affinity purification
Gene ID:
51284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse liver, using TLR7 antibody (CAB0991) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
