The TM7SF3 Antibody (PACO30442) is a polyclonal antibody specifically designed for research involving TM7SF3, a protein involved in lipid metabolism and cholesterol biosynthesis. This antibody, derived from rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TM7SF3 protein, this antibody enables the detection and analysis of TM7SF3 in various cell types, making it an essential tool for studies in metabolic pathways and lipid-related diseases.TM7SF3 is a key player in the regulation of cholesterol levels and lipid metabolism, making it a promising target for research into conditions such as atherosclerosis, cardiovascular disease, and metabolic disorders.
By understanding the function and regulation of TM7SF3, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention. The TM7SF3 Antibody (PACO30442) is a valuable tool for researchers seeking to explore the role of TM7SF3 and its implications in human health and disease.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO30442 at dilution of 1:100.
Immunofluorescent analysis of U251 cells using PACO30442 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
extracellular exosome
Synonyms:
Transmembrane 7 superfamily member 3 (Seven span transmembrane protein), TM7SF3
UniProt Protein Function:
Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623).
