The TMEM2 Polyclonal Antibody (CAB18439) is a crucial tool for researchers studying TMEM2, a transmembrane protein involved in various cellular functions. This rabbit-derived antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the TMEM2 protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it an invaluable asset for studies in molecular biology and cell biology.TMEM2, also known as transmembrane protein 2, is a key player in cell signaling and membrane transport processes, with implications in cancer biology, neurobiology, and developmental biology.
Understanding the role of TMEM2 is essential for unraveling its diverse functions and potential therapeutic applications. With its high reactivity and specificity, the TMEM2 Polyclonal Antibody (CAB18439) offers researchers a reliable tool for investigating the biology of TMEM2 in health and disease.
Product Name:
TMEM2 Rabbit Polyclonal Antibody
SKU:
CAB18439
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human TMEM2 (NP_037522.1).
This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.
Purification Method:
Affinity purification
Gene ID:
23670
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung, using TMEM2 Rabbit pAb (CAB18439) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
