The TMEM237 Polyclonal Antibody (PACO05072) is a valuable tool for researchers studying TMEM237, a protein involved in ciliogenesis and cilia function. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the TMEM237 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in cell biology and ciliopathy research.TMEM237 is a transmembrane protein localized in the ciliary transition zone, where it plays a crucial role in cilia assembly and maintenance.
Dysregulation of TMEM237 has been linked to ciliopathies, genetic disorders characterized by abnormal cilia structure and function. Research on TMEM237 is essential for understanding the mechanisms underlying cilia-related diseases and developing potential therapeutic interventions targeting cilia dysfunction. The TMEM237 Polyclonal Antibody is a valuable tool for investigating the complex functions of TMEM237 and advancing our knowledge of cilia biology.
Antibody Name:
TMEM237 Antibody (PACO05072)
Antibody SKU:
PACO05072
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from the Internal region of human ALS2CR4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TMEM237; ALS2CR4; Transmembrane protein 237; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein
UniProt Protein Function:
ALS2CR4: Component of the transition zone in primary cilia. Required for ciliogenesis. Defects in TMEM237 are the cause of Joubert syndrome type 14 (JBTS14). An autosomal recessive disorder characterized by severe mental retardation, hypotonia, breathing abnormalities in infancy, and dysmorphic facial features. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable JBTS14 features include renal disease, abnormal eye movements, and postaxial polydactyly. Belongs to the TMEM237 family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2q33.2Cellular Component: membrane; integral to membraneBiological Process: regulation of Wnt receptor signaling pathway; cilium biogenesisDisease: Joubert Syndrome 1; Joubert Syndrome 14
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
