The TMPRSS11F Polyclonal Antibody (PACO20716) is a powerful tool for researchers studying TMPRSS11F, an enzyme involved in proteolytic cleavage of proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blotting applications. By binding to TMPRSS11F, this antibody allows for accurate detection and analysis in various cell types, making it an invaluable asset for studies in molecular biology and disease research.TMPRSS11F, also known as transmembrane protease serine 11F, plays a crucial role in protein processing and activation, making it a key player in various physiological and pathological processes.
Its involvement in protein cleavage makes it a promising target for research related to viral infections, cancer metastasis, and inflammatory diseases. Understanding the function of TMPRSS11F is essential for developing targeted therapies and diagnostic tools for conditions associated with protein dysregulation.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO20716(TMPRSS11F Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Human thyroid tissue, Human esophagus cancer tissue, human normal rectum tissue, Primary antibody: PACO20716(TMPRSS11F Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20716(TMPRSS11F Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
TMPRSS11F is a type-II transmembrane protease, similar to hepsin (TMPRSS1). TMPRSS11F is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase-1, 2 and 3. TMPRSS11F has a domain structure of an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a SEA domain (Sea urchin sperm protein, Enterokinase, Agrin), a short spacer, then the trypsin-like serine protease domain. The SEA domain is thought to play a role in carbohydrate binding in the analogous protein sequences where it is found, but its role in TMPRSS11F is unclear. The cleavage of the Arg206-Ile207 bond is thought to liberate the catalytic domain.
Synonyms:
transmembrane protease, serine 11F
UniProt Protein Function:
TMPRSS11F: Probable serine protease. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Protease; Membrane protein, integralChromosomal Location of Human Ortholog: 4q13.2Cellular Component: integral to plasma membrane; extracellular regionMolecular Function: serine-type endopeptidase activityBiological Process: proteolysis
