The TMPRSS11F Monoclonal Antibody (PAC020717) is a vital tool for researchers studying the TMPRSS11F protein, a member of the type II transmembrane serine protease family. This antibody, produced using hybridoma technology, exhibits high specificity and sensitivity for TMPRSS11F in a variety of applications, including immunohistochemistry and flow cytometry.TMPRSS11F is known for its involvement in various physiological processes, such as cell proliferation, differentiation, and apoptosis. Its dysregulation has been linked to diseases like cancer, where it plays a role in tumor progression and metastasis.
By targeting TMPRSS11F with this antibody, researchers can gain insights into its function and potential as a therapeutic target in cancer research.This antibody's ability to accurately detect and quantify TMPRSS11F expression in different cell types and tissues makes it an invaluable tool for investigating the molecular mechanisms underlying cancer development and progression. Its reliability and versatility make it a valuable asset for scientists studying proteases and their role in disease pathology.
Antibody Name:
TMPRSS11F Antibody (PACO20717)
Antibody SKU:
PACO20717
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human TMPRSS11F
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-2: Human esophagus tissue, Human thyroid cancer tissue, Primary antibody: PACO20717(TMPRSS11F Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
TMPRSS11F is a type-II transmembrane protease, similar to hepsin (TMPRSS1). TMPRSS11F is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase-1, 2 and 3. TMPRSS11F has a domain structure of an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a SEA domain (Sea urchin sperm protein, Enterokinase, Agrin), a short spacer, then the trypsin-like serine protease domain. The SEA domain is thought to play a role in carbohydrate binding in the analogous protein sequences where it is found, but its role in TMPRSS11F is unclear. The cleavage of the Arg206-Ile207 bond is thought to liberate the catalytic domain.
Synonyms:
transmembrane protease, serine 11F
UniProt Protein Function:
TMPRSS11F: Probable serine protease. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Protease; Membrane protein, integralChromosomal Location of Human Ortholog: 4q13.2Cellular Component: integral to plasma membrane; extracellular regionMolecular Function: serine-type endopeptidase activityBiological Process: proteolysis
