Description
TMPRSS3 Antibody (PACO01637)
The TMPRSS3 Polyclonal Antibody (PACO01637) is a valuable tool for researchers studying TMPRSS3, a transmembrane serine protease that plays a role in various physiological processes. The antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By binding to the TMPRSS3 protein, this antibody enables the detection and analysis of TMPRSS3 in different cell types, making it an essential reagent for investigations in molecular biology and disease research.
TMPRSS3 is known for its involvement in proteolytic cleavage events that are crucial for the activation of several proteins, including growth factors and cell surface receptors. Dysregulation of TMPRSS3 has been linked to various diseases, making it a target of interest for studies on cancer, infectious diseases, and developmental disorders. Elucidating the functions of TMPRSS3 is essential for unraveling its role in these pathological conditions and for identifying potential therapeutic targets for intervention.
| Antibody Name: | TMPRSS3 Antibody |
| Antibody SKU: | PACO01637 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the C-terminal region of human TMPRSS3. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | TMPRSS3; ECHOS1; TADG12; Transmembrane protease serine 3; Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein |
| UniProt Protein Function: | TMPRSS3: Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8). DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10). Belongs to the peptidase S1 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; Membrane protein, integral; Endoplasmic reticulum; EC 3.4.21.- Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane Molecular Function:sodium channel regulator activity Biological Process: cellular sodium ion homeostasis Disease: Deafness, Autosomal Recessive 8 |
| NCBI Summary: | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P57727 |
| NCBI GenInfo Identifier: | 13124582 |
| NCBI Gene ID: | 64699 |
| NCBI Accession: | P57727.2 |
| UniProt Secondary Accession: | P57727,Q5USC7, Q6ZMC3, D3DSJ6, |
| UniProt Related Accession: | P57727 |
| Molecular Weight: | 58,324 Da |
| NCBI Full Name: | Transmembrane protease serine 3 |
| NCBI Synonym Full Names: | transmembrane protease, serine 3 |
| NCBI Official Symbol: | TMPRSS3Â Â |
| NCBI Official Synonym Symbols: | DFNB8; DFNB10; ECHOS1; TADG12Â Â |
| NCBI Protein Information: | transmembrane protease serine 3 |
| UniProt Protein Name: | Transmembrane protease serine 3 |
| UniProt Synonym Protein Names: | Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein |
| Protein Family: | Transmembrane protease serine |
| UniProt Gene Name: | TMPRSS3Â Â |
| UniProt Entry Name: | TMPS3_HUMAN |
