The Anti-TNFRSF17 Antibody (CAB10707) is a highly specific tool for studying TNFRSF17, also known as BCMA, a cell surface receptor involved in B cell development and immune response regulation. This polyclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications.TNFRSF17, a member of the tumor necrosis factor receptor superfamily, plays a pivotal role in B cell survival and differentiation, making it a key target for investigating diseases such as multiple myeloma and other B cell-related disorders.
By binding to the TNFRSF17 protein, this antibody enables precise detection and analysis in various cell types, facilitating research in immunology and oncology.The Anti-TNFRSF17 Antibody is essential for elucidating the functions of TNFRSF17 in immunity and disease pathogenesis, providing valuable insights for the development of targeted therapies and precision medicine approaches. Its specificity and high reactivity make it an indispensable tool for researchers studying TNFRSF17 signaling pathways and its potential as a therapeutic target in various clinical settings.
Product Name:
TNFRSF17 Rabbit Polyclonal Antibody
SKU:
CAB10707
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TNFRSF17 (NP_001183.2).
Cell membrane, Endomembrane system, Single-pass type III membrane protein.
Calculated MW:
20kDa
Observed MW:
15-35kDa
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Purification Method:
Affinity purification
Gene ID:
608
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFRSF17 antibody (CAB10707) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
