The TNFRSF21 Polyclonal Antibody (CAB7365) is an essential tool for researchers studying TNFRSF21, a cell surface receptor involved in immune signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting TNFRSF21 in human samples, making it a valuable asset for Western blot applications. By binding to the TNFRSF21 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in immunology and oncology research.
TNFRSF21, also known as DR6, plays a key role in immune regulation and cell death pathways, making it a crucial target for understanding diseases such as cancer, autoimmune disorders, and neurodegenerative conditions. By elucidating the function of TNFRSF21, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention. The TNFRSF21 Polyclonal Antibody is a valuable tool for advancing research in these critical areas of study.
Product Name:
TNFRSF21 Rabbit Polyclonal Antibody
SKU:
CAB7365
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 371-655 of human TNFRSF21 (NP_055267.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
72kDa
Observed MW:
110kDa
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.
Purification Method:
Affinity purification
Gene ID:
27242
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TNFRSF21 antibody (CAB7365) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
