The TOR1AIP1 Polyclonal Antibody (PACO01013) is a valuable tool for researchers studying TOR1AIP1, a protein involved in cellular functions such as nuclear envelope organization and nuclear migration. This antibody, raised in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications. By binding to the TOR1AIP1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for research in cell biology and nuclear dynamics.TOR1AIP1 plays a crucial role in maintaining the structural integrity of the nuclear envelope and facilitating the movement of cell nuclei, processes that are essential for proper cell function and organization.
Dysregulation of TOR1AIP1 has been implicated in various diseases, including muscular dystrophies and neurodegenerative disorders, making it a promising target for therapeutic interventions. Understanding the function and regulation of TOR1AIP1 is crucial for advancing knowledge in these disease areas and developing potential treatments.
Antibody Name:
TOR1AIP1 Antibody
Antibody SKU:
PACO01013
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human LAP1B.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TOR1AIP1; Torsin-1A-interacting protein 1; Lamin-associated protein 1B; LAP1B
UniProt Protein Function:
TOR1AIP1: Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. Belongs to the TOR1AIP family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 1q24.2Cellular Component: nucleusMolecular Function: ATPase activator activity; ATPase binding; cytoskeletal protein binding; protein bindingBiological Process: positive regulation of ATPase activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
