The TPCN2 Polyclonal Antibody (CAB17271) is a valuable tool for researchers studying the TPCN2 protein, which is involved in the regulation of calcium release from lysosomes and plays a crucial role in various cellular processes. This antibody is produced in rabbits and has been validated for Western blot applications, demonstrating high reactivity with human samples.TPCN2, also known as two-pore channel 2, is a key player in calcium signaling pathways and is implicated in diseases such as lysosomal storage disorders, neurodegenerative diseases, and cancer.
By targeting TPCN2 with this antibody, researchers can detect and analyze the protein in different cell types, providing insights into its function and potential therapeutic applications.The TPCN2 Polyclonal Antibody is a valuable tool for investigations in cell biology, physiology, and disease pathology. Its specificity and sensitivity make it an essential component for studies focused on understanding the role of TPCN2 in cellular calcium homeostasis and its implications in various health conditions.
Product Name:
TPCN2 Polyclonal Antibody
SKU:
CAB17271
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 11-85 of human TPCN2 (NP_620714.2).
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.
Purification Method:
Affinity purification
Gene ID:
219931
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using TPCN2 Rabbit pAb (CAB17271) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 300s.
