Anti-Trem2 Antibody (PACO30798)

Antibody Name:	Trem2 Antibody (PACO30798)
Antibody SKU:	PACO30798
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:	Mouse, Human
Immunogen:	Recombinant Mouse Triggering receptor expressed on myeloid cells 2 protein (19-171AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot
All lanes: Trem2 antibody at 6µg/ml
Lane 1: Mouse liver tissue
Lane 2: THP-1 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 25, 28 kDa
Observed band size: 28 kDa
.

Background:	May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
Synonyms:	Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2), Trem2, Trem2a Trem2b Trem2c

UniProt Protein Function:	TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Cellular Component: integral to membrane; intracellular membrane-bound organelle Molecular Function:lipopolysaccharide binding; peptidoglycan binding; protein binding; transmembrane receptor activity Biological Process: detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; lipopolysaccharide-mediated signaling pathway; phagocytosis, engulfment; positive regulation of antigen processing and presentation of peptide antigen via MHC class II; positive regulation of calcium-mediated signaling; positive regulation of peptidyl-tyrosine phosphorylation
NCBI Summary:	The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
UniProt Code:	Q99NH8
NCBI GenInfo Identifier:	50401660
NCBI Gene ID:	83433
NCBI Accession:	Q99NH8.1
UniProt Secondary Accession:	Q99NH8,Q8CGK4, Q8CIA6, Q99NH9, Q9JL34,
UniProt Related Accession:	Q99NH8
Molecular Weight:	27,304 Da
NCBI Full Name:	Triggering receptor expressed on myeloid cells 2
NCBI Synonym Full Names:	triggering receptor expressed on myeloid cells 2
NCBI Official Symbol:	Trem2
NCBI Official Synonym Symbols:	TREM-2; Trem2a; Trem2b; Trem2c
NCBI Protein Information:	triggering receptor expressed on myeloid cells 2
UniProt Protein Name:	Triggering receptor expressed on myeloid cells 2
UniProt Synonym Protein Names:	Triggering receptor expressed on monocytes 2
Protein Family:	Triggering receptor expressed on myeloid cells
UniProt Gene Name:	Trem2
UniProt Entry Name:	TREM2_MOUSE

ELISA Kits

Mouse TREM2 ELISA Kit

Mouse Triggering receptor expressed on myeloid cells 2 (Trem2) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)