The TRIM14 Polyclonal Antibody (PACO12903) is a vital tool for researchers studying the TRIM14 protein, an important regulator of immune responses and antiviral defense mechanisms. This antibody, produced in rabbits, exhibits high specificity and sensitivity when used in Western blot applications with human samples. By targeting the TRIM14 protein, researchers can delve into its functions in various cell types, particularly in the fields of immunology and virology.TRIM14 is recognized for its role in innate immunity, specifically in the activation of antiviral signaling pathways and the regulation of inflammatory responses.
Its involvement in immune defense against viral infections and potential implications in autoimmune diseases make it a promising target for therapeutic research. By investigating the functions of TRIM14, researchers may uncover new insights into immune regulation and potential treatment strategies for viral infections and autoimmune conditions.
TRIM14: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 9q22.33Cellular Component: cytoplasm; intracellularMolecular Function: zinc ion bindingBiological Process: negative regulation of viral transcription; innate immune response; positive regulation of transcription factor activity; activation of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
