The TRIM14 Polyclonal Antibody (PAC020691) is a valuable tool for researchers studying TRIM14, a protein involved in immune regulation and antiviral responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the TRIM14 protein, this antibody enables detection and analysis in various cell types, making it an ideal choice for investigations in immunology, virology, and infectious disease research.TRIM14, also known as a tripartite motif-containing protein, plays a crucial role in innate immunity by promoting the production of antiviral cytokines and regulating inflammatory responses.
Its involvement in immune signaling pathways makes TRIM14 a promising target for studying viral infections, autoimmune diseases, and other immune-related disorders. Expanding our understanding of TRIM14 function is essential for developing new therapeutic strategies that enhance antiviral immunity or modulate inflammatory pathways.
Antibody Name:
TRIM14 Antibody (PACO20691)
Antibody SKU:
PACO20691
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human TRIM14
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20691(TRIM14 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants.
Synonyms:
tripartite motif containing 14
UniProt Protein Function:
TRIM14: Inhibits the transcriptional activity of SPI1 in a dose- dependent manner. Belongs to the TRIM/RBCC family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 9q22.33Cellular Component: cytoplasm; intracellularMolecular Function: zinc ion bindingBiological Process: negative regulation of viral transcription; innate immune response; positive regulation of transcription factor activity; activation of NF-kappaB transcription factor
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
