The TRIP6 Polyclonal Antibody (PAC012929) is a valuable tool for researchers studying TRIP6, a protein that plays a key role in cell adhesion and signaling pathways. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the TRIP6 protein, this antibody enables the detection and analysis of TRIP6 in various cell types, making it an ideal choice for studies in cell biology and cancer research.TRIP6, also known as thyroid receptor interactor 6, is involved in regulating cell migration, invasion, and cytoskeletal dynamics.
Its interactions with various signaling molecules make it a crucial player in processes such as cell adhesion and cell proliferation. Research on TRIP6 has implications for understanding the mechanisms underlying cancer metastasis and invasion, as well as potential therapeutic targets for cancer treatment.By utilizing the TRIP6 Polyclonal Antibody, researchers can gain valuable insights into the functions and regulation of TRIP6 in different cellular processes, paving the way for advancements in cancer biology and the development of targeted therapies.
TRIP6: thyroid receptor interacting protein 6 specifically interacts with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13. Functions downstream of the activated LPA(2) receptor and is involved in cell adhesion and migration.Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Adaptor/scaffoldChromosomal Location of Human Ortholog: 7q22Cellular Component: interleukin-1 receptor complex; cytoskeleton; focal adhesion; cytoplasm; plasma membrane; nucleusMolecular Function: protein binding; interleukin-1 receptor binding; zinc ion binding; thyroid hormone receptor binding; kinase bindingBiological Process: release of cytoplasmic sequestered NF-kappaB; focal adhesion formation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell migration
UniProt Protein Details:
NCBI Summary:
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
thyroid receptor-interacting protein 6; zyxin related protein 1; TR-interacting protein 6; OPA-interacting protein 1; thyroid hormone receptor interacting protein 6
UniProt Protein Name:
Thyroid receptor-interacting protein 6
UniProt Synonym Protein Names:
Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1
