The TSHZ1 Polyclonal Antibody (PACO03323) is a high-quality antibody developed for research on TSHZ1, a transcription factor known for its role in development and cell differentiation. This antibody, produced in rabbits, specifically targets human samples and has been validated for use in Western blot applications. By binding to the TSHZ1 protein, researchers can accurately detect and analyze TSHZ1 expression in various cell types, making it an ideal tool for studies in developmental biology and cancer research.TSHZ1 is a key player in the regulation of gene expression during development, particularly in embryonic tissue formation and organ differentiation.
Understanding the function of TSHZ1 is essential for unraveling the molecular mechanisms underlying developmental processes and disease pathogenesis. Research on TSHZ1 can provide valuable insights into conditions such as congenital disorders, developmental abnormalities, and cancer progression, offering potential targets for therapeutic interventions aimed at modulating gene expression and cellular differentiation.
Antibody Name:
TSHZ1 Antibody
Antibody SKU:
PACO03323
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human TSHZ1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
TSHZ1; SDCCAG33; TSH1; Teashirt homolog 1; Antigen NY-CO-33; Serologically defined colon cancer antigen 33
UniProt Protein Function:
TSHZ1: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Defects in TSHZ1 are the cause of congenital aural atresia (CAA). A rare anomaly of the ear that involves some degree of failure of the development of the external auditory canal. The malformation can also involve the tympanic membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent middle-ear cavity. Belongs to the teashirt C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 18q22.3Disease: Aural Atresia, Congenital
UniProt Protein Details:
NCBI Summary:
This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]
