The TSSC1 Monoclonal Antibody (PAC017329) is a valuable tool for researchers studying TSSC1, a protein involved in telomere maintenance and DNA replication. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in techniques such as immunofluorescence and flow cytometry. By targeting the TSSC1 protein, researchers can investigate its role in cellular processes and potentially uncover new insights into cancer development, aging, and genetic disorders.TSSC1, also known as Shelterin complex subunit TIN2, is a key component of the telomere protection complex that maintains chromosome stability and regulates cell proliferation.
Dysregulation of TSSC1 has been linked to telomere dysfunction and genomic instability, highlighting its importance in maintaining cellular health. By studying the function of TSSC1, researchers may uncover potential therapeutic targets for diseases associated with telomere shortening, such as cancer and premature aging syndromes.
Antibody Name:
TSSC1 Antibody (PACO17329)
Antibody SKU:
PACO17329
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human TSSC1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17329(TSSC1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11.
Synonyms:
tumor suppressing subtransferable candidate 1
UniProt Protein Function:
TSSC1: Chromosomal Location of Human Ortholog: 2p25.3
UniProt Protein Details:
NCBI Summary:
This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]
