The TTBK1 Polyclonal Antibody (PAC020783) is a vital tool for researchers investigating TTBK1, a key enzyme involved in various cellular processes such as cell cycle regulation and ciliary function. This antibody, produced using rabbit immunization, exhibits high specificity for human samples and is ideal for Western blot applications.TTBK1, also known as tau tubulin kinase 1, plays a crucial role in microtubule dynamics and ciliary function, making it a promising target for studying diseases related to these pathways. The antibody binds specifically to TTBK1 protein, enabling detection and quantification in different cell types and tissues.
Researchers in the fields of cell biology and neurology can benefit from the use of this antibody in their studies on neurodegenerative disorders and ciliopathies.Understanding the function and regulation of TTBK1 is essential for uncovering its roles in health and disease, with implications for the development of potential therapeutic interventions targeting TTBK1-related pathways. Researchers can trust the reliability and specificity of the TTBK1 Polyclonal Antibody for their experimental needs.
Antibody Name:
TTBK1 Antibody (PACO20783)
Antibody SKU:
PACO20783
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human TTBK1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20783(TTBK1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20783(TTBK1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
TTBK1 (tau tubulin kinase 1), also known as BDTK (brain-derived tau kinase), is a 1,321 amino acid, protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of tubulin dynamics.
Synonyms:
tau tubulin kinase 1
UniProt Protein Function:
TTBK1: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; CK1 group; TTBK familyChromosomal Location of Human Ortholog: 6p21.1Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; ATP bindingBiological Process: regulation of cell shape; peptidyl-serine phosphorylation; substantia nigra development
