Description
TTR Monoclonal Antibody (CAB4067)
The TTR Monoclonal Antibody (CAB4067) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, developed using advanced rabbit monoclonal technology, demonstrates high specificity and sensitivity for detecting TTR in human samples.TTR is a biomarker for various diseases, including familial amyloid polyneuropathy (FAP) and senile systemic amyloidosis. The TTR Rabbit Monoclonal Antibody is optimized for use in immunohistochemistry, immunofluorescence, and other research applications, providing researchers with a reliable tool for investigating TTR expression and distribution in tissue samples.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | TTR Monoclonal Antibody |
| SKU: | CAB4067 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Clone Number: | ARC0892 |
| Conjugate: | Unconjugated |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. | ||||
| Sequence: | KTSE SGEL HGLT TEEE FVEG IYKV EIDT KSYW KALG ISPF HEHA EVVF TAND SGPR RYTI AALL SPYS YSTT AVVT NPKE | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | CTS, TTN, ATTR, CTS1, PALB, TBPA, HEL111, HsT2651, TTR |
| Positive Sample: | Human plasma |
| Cellular Localization: | Cytoplasm, Secreted. |
| Calculated MW: | 16kDa |
| Observed MW: | 16kDa/30kDa |
This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
| Purification Method | Affinity purification |
| Gene ID | 7276 |
| RRID | AB_2863181 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of lysates from Human plasma, using TTR Rabbit mAb (CAB4067) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s. |
