The TULP3 Polyclonal Antibody (PAC012992) is a valuable tool for researchers studying TULP3, a critical protein involved in cellular processes such as vesicle trafficking and protein transport. This rabbit-derived antibody is highly specific to human samples and is validated for Western blot applications, allowing for precise detection and analysis of TULP3 protein levels in a variety of cell types.TULP3, short for Tubby like protein 3, is essential for maintaining cellular homeostasis and has been linked to various diseases including retinal degeneration and obesity.
By targeting TULP3, researchers can gain insights into the underlying mechanisms of these conditions and potentially develop new therapeutic strategies.With its high reactivity and specificity, the TULP3 Polyclonal Antibody (PAC012992) is an invaluable tool for immunology and cell biology research focused on understanding the role of TULP3 in health and disease.
TULP3: Negatively regulates SHH signal transduction. Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. Belongs to the TUB family.Chromosomal Location of Human Ortholog: 12p13.3Cellular Component: cilium; nucleolus; nucleus; plasma membraneMolecular Function: enzyme binding; phosphoinositide binding; protein binding; protein complex bindingBiological Process: negative regulation of smoothened signaling pathway; regulation of G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009]
