The TUT1 Antibody (PACO05061) is a polyclonal antibody designed for research involving the TUT1 protein, a key enzyme involved in mRNA processing and regulation. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for studying the role of TUT1 in gene expression and RNA metabolism.TUT1 is known to be involved in adding non-templated nucleotides to the 3' end of RNA molecules, a process important for mRNA stability and translation efficiency. Dysregulation of TUT1 has been implicated in various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.
This antibody has been validated for use in Western blot applications, enabling researchers to detect and analyze TUT1 protein levels in different cell types and tissues. By understanding the function and regulation of TUT1, researchers can gain valuable insights into the mechanisms underlying mRNA processing and potentially develop novel approaches for treating diseases associated with RNA dysregulation.
Antibody Name:
TUT1 Antibody (PACO05061)
Antibody SKU:
PACO05061
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human TUTase.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
RBM21: Highly specific terminal uridylyltransferase that exclusively accepts U6 snRNA as substrate. U6 snRNA is unique in that nucleotides are both added to and removed from its 3'-end. U6-TUTase is responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Does not play a role in replication-dependent histone mRNA degradation.Protein type: Nucleolus; EC 2.7.7.52; EC 2.7.7.19; TransferaseChromosomal Location of Human Ortholog: 11q12.2Cellular Component: nucleoplasm; intercellular bridge; nucleolus; nuclear speck; mRNA cleavage and polyadenylation specificity factor complexMolecular Function: polynucleotide adenylyltransferase activity; protein binding; enzyme binding; mRNA 3'-UTR binding; RNA binding; metal ion binding; RNA uridylyltransferase activity; ATP bindingBiological Process: snRNA processing; mRNA polyadenylation; mRNA cleavage
UniProt Protein Details:
NCBI Summary:
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]
