The TYK2 Polyclonal Antibody (CAB2128) is a valuable tool for researchers studying the TYK2 protein, a member of the JAK family of kinases involved in cytokine signaling and immune response regulation. This antibody, generated in rabbits, exhibits high specificity for human TYK2 samples and is validated for Western blot applications. By binding to TYK2, the antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in immunology and cancer research.
TYK2 is known for its role in mediating signaling pathways triggered by cytokines, regulating immune responses and inflammatory processes. Dysfunction in TYK2 has been associated with autoimmune diseases, cancer, and infectious diseases, making it a target of interest for therapeutic interventions. The TYK2 Polyclonal Antibody aids in understanding the functions of TYK2, providing valuable insights for the development of targeted treatments and immunotherapies in various disease contexts.
Product Name:
TYK2 Rabbit Polyclonal Antibody
SKU:
CAB2128
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1102-1182 of human TYK2 (NP_003322.3).
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35.
Purification Method:
Affinity purification
Gene ID:
7297
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using TYK2 Rabbit pAb (CAB2128) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
