The UBTD2 Polyclonal Antibody (PAC020810) is a valuable tool for researchers studying UBTD2, a protein involved in the ubiquitination pathway. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is optimized for Western blot applications. By binding to UBTD2, the antibody enables precise detection and analysis of this protein in various cell types, making it an excellent choice for investigations in molecular biology and cell signaling.UBTD2 is a key player in the ubiquitin system, which regulates protein degradation and turnover within cells.
Dysregulation of this pathway has been linked to numerous diseases, including cancer, neurodegenerative disorders, and infectious diseases. As such, UBTD2 represents a promising target for therapeutic intervention and further research into disease mechanisms. By studying UBTD2's functions and interactions, researchers can gain valuable insights into cellular processes and potentially identify novel drug targets for treating a range of pathologies.
Antibody Name:
UBTD2 Antibody (PACO20810)
Antibody SKU:
PACO20810
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human UBTD2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20810(UBTD2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20810(UBTD2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
UBTD2 (ubiquitin domain containing 2), also known as DCUBP (dendritic cell-derived ubiquitin-like protein), DC-UbP or SB72, is a 234 amino acid, cytoplasmic and mitochondrial ubiquitin-like (UbL) protein that contains one C-terminal UbL domain. UbL proteins are involved in a variety of cellular processes, including DNA repair, protein sorting, apoptosis, protein degradation, cell division and autophagy. Predominantly expressed in dendritic cells and detected at high levels in tumor cell lines, UBTD2 has been implicated in apoptosis, cellular differentiation and tumorigenesis. The UbL domain of UBTD2 is 55% similar and 28.6% identical to the amino acid, sequence of ubiquitin, but it lacks the Gly-Gly motif that is essential for ubiquitination. As its UbL domain does not actively ubiquitinate proteins, UBTD2 is believed to function as a shuttle factor involved in the ubiquitin system.
Synonyms:
ubiquitin domain containing 2
UniProt Protein Function:
UBTD2: Chromosomal Location of Human Ortholog: 5q35.1Cellular Component: cytoplasmMolecular Function: ubiquitin binding
