The UCK1 Polyclonal Antibody (PAC030972) is a valuable tool for researchers studying UCK1, an essential enzyme involved in pyrimidine biosynthesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards UCK1 in human samples, making it ideal for Western blot applications. By binding to the UCK1 protein, this antibody enables accurate detection and analysis across a range of cell types.UCK1 plays a pivotal role in nucleotide metabolism, making it a key target for investigating diseases such as cancer and genetic disorders.
By studying the function and regulation of UCK1, researchers can gain insights into mechanisms underlying these conditions and potentially identify novel therapeutic strategies. The UCK1 Polyclonal Antibody is a valuable tool for advancing research in molecular biology, biochemistry, and drug development.
Antibody Name:
UCK1 Antibody (PACO30972)
Antibody SKU:
PACO30972
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Uridine-cytidine kinase 1 protein (1-201AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO30972 at dilution of 1:100.
Background:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
UCK1: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. Belongs to the uridine kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 2.7.1.48Chromosomal Location of Human Ortholog: 9q34.13Cellular Component: cytosolMolecular Function: nucleoside kinase activity; uridine kinase activityBiological Process: pyrimidine base metabolic process; pyrimidine nucleoside salvage
UniProt Protein Details:
NCBI Summary:
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
