The UGT2A3 Polyclonal Antibody (PAC037086) is a valuable tool for researchers studying UGT2A3, a member of the UDP-glucuronosyltransferase family involved in drug metabolism and detoxification processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the UGT2A3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for studies in pharmacology and toxicology.
UGT2A3 plays a crucial role in the metabolism of various endogenous and exogenous compounds, including drugs, environmental toxins, and dietary components. Understanding the function and regulation of UGT2A3 is essential for predicting drug interactions, metabolic pathways, and potential toxicity issues. Therefore, this antibody serves as a valuable tool for investigating the role of UGT2A3 in drug metabolism and related pathways, with potential implications for personalized medicine and drug development.
Antibody Name:
UGT2A3 Antibody (PACO37086)
Antibody SKU:
PACO37086
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human UDP-glucuronosyltransferase 2A3 protein (201-491AA)
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO37086 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO37086 at dilution of 1:100.
Background:
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid, to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
UGT2A3: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Belongs to the UDP-glycosyltransferase family.Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - pentose and glucuronate interconversions; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - ascorbate and aldarate; Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 2.4.1.17; Carbohydrate Metabolism - starch and sucroseChromosomal Location of Human Ortholog: 4q13.2Cellular Component: intracellular membrane-bound organelleMolecular Function: glucuronosyltransferase activityBiological Process: flavonoid biosynthetic process
