The UNC13D Antibody (CAB13141) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.The UNC13D protein, also known as MUNC13-4, is essential for the function of cytolytic cells in the immune system, allowing for the release of cytotoxic granules that target infected or malignant cells.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
UNC13D Antibody
SKU:
CAB13141
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
FHL3, HLH3, HPLH3, Munc13-4, UNC13D
Positive Sample:
A-549, HeLa, HepG2, Mouse lung
Cellular Localization:
Cytoplasm, Late Endosome, Lysosome, Membrane, Peripheral Membrane Protein, Recycling Endosome.
Calculated MW:
123kDa
Observed MW:
123kDa
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Purification Method
Affinity purification
Gene ID
201294
RRID
AB_2759991
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UNC13D Rabbit pAb (CAB13141) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
