The UNG Polyclonal Antibody (CAB13155) is a high-quality research tool designed for studying Uracil-DNA Glycosylase (UNG) protein. UNG is an enzyme involved in DNA repair, specifically in the base excision repair pathway. This antibody, raised in rabbits, is highly specific to human UNG and has been validated for Western blot applications.With its ability to bind specifically to the UNG protein, this antibody enables accurate detection and analysis of UNG in various cell types. This makes it an ideal tool for researchers studying DNA repair mechanisms, mutagenesis, and genotoxicity.
Additionally, understanding the role of UNG in DNA repair processes is crucial for developing therapies targeting diseases associated with DNA damage, such as cancer and genetic disorders.Overall, the UNG Polyclonal Antibody (CAB13155) offers researchers a reliable and specific tool for investigating the function and regulation of UNG in cellular processes, providing valuable insights into DNA repair mechanisms and potential therapeutic targets.
Product Name:
UNG Rabbit Polyclonal Antibody
SKU:
CAB13155
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UNG (NP_550433.1).
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
Purification Method:
Affinity purification
Gene ID:
7374
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using UNG Rabbit pAb (CAB13155) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
