The VPS26A Polyclonal Antibody (PACO20864) is a crucial tool for researchers studying VPS26A, a key protein involved in cellular trafficking and sorting of proteins within cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards VPS26A in human samples, making it ideal for use in Western blot applications.VPS26A is a component of the retromer complex, which plays a critical role in the recycling of cell surface receptors and the maintenance of cellular homeostasis. Dysregulation of VPS26A function has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes, making it an attractive target for therapeutic intervention.
By using the VPS26A Polyclonal Antibody, researchers can accurately detect and analyze VPS26A expression levels in different cell types, providing valuable insights into its role in cellular processes and disease pathogenesis. This antibody is an essential tool for advancing our understanding of VPS26A function and its potential as a therapeutic target in various diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20864(VPS26A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-7: 293T cells, A431 cells, Hela cells, HepG2 cells, Human fetal liver tissue, PC3 cells, Human placenta tissue,Primary antibody: PACO20864(VPS26A Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20864(VPS26A Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms:
vacuolar protein sorting 26 homolog A (S. pombe)
UniProt Protein Function:
VPS26A: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Belongs to the VPS26 family.
Molecular Function:protein binding; protein transporter activity
Biological Process: intracellular protein transport; regulation of macroautophagy; retrograde transport, endosome to Golgi; Wnt receptor signaling pathway
NCBI Summary:
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
