The VPS37D Polyclonal Antibody (PAC017446) is a vital tool for researchers studying VPS37D, a key component of the endosomal sorting complex required for transport (ESCRT-I) machinery. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting VPS37D in human samples, making it suitable for Western blotting applications. By targeting the VPS37D protein, this antibody allows for precise identification and analysis in a variety of cell types, making it an essential resource for investigations in cell biology and molecular biology.VPS37D is involved in the sorting of ubiquitinated cargo proteins into multivesicular bodies (MVBs), a process critical for endosomal protein trafficking and degradation.
Dysfunction of VPS37D has been linked to various diseases, including neurodegenerative disorders and viral infections. Research on VPS37D is vital for understanding the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies targeting the ESCRT machinery. By utilizing the VPS37D Polyclonal Antibody, researchers can further explore the role of VPS37D in cellular processes and disease pathogenesis, ultimately advancing our knowledge of ESCRT biology and its implications for human health.
Antibody Name:
VPS37D Antibody (PACO17446)
Antibody SKU:
PACO17446
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human VPS37D
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17446(VPS37D Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17446(VPS37D Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Synonyms:
vacuolar protein sorting 37 homolog D (S. cerevisiae)
UniProt Protein Function:
VPS37D: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the VPS37 family.Chromosomal Location of Human Ortholog: 7q11.23Cellular Component: endosome membraneBiological Process: autophagy; endosome transport; viral infectious cycle
