The VPS37D Polyclonal Antibody (PAC017447) is a valuable tool for researchers studying VPS37D, a key protein involved in endosome-to-Golgi retrieval and endosome maturation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the VPS37D protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and intracellular trafficking.VPS37D is essential for the function of the retromer complex, which plays a crucial role in protein sorting and trafficking within cells.
Dysregulation of VPS37D has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. Investigating the function and regulation of VPS37D is crucial for understanding these disease processes and developing targeted therapeutic interventions.By utilizing the VPS37D Polyclonal Antibody (PAC017447), researchers can gain valuable insights into the role of VPS37D in cellular processes and disease pathogenesis, ultimately advancing our understanding of intracellular trafficking and offering potential therapeutic strategies for a range of disorders.
Antibody Name:
VPS37D Antibody (PACO17447)
Antibody SKU:
PACO17447
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human VPS37D
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17447(VPS37D Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17447(VPS37D Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Synonyms:
vacuolar protein sorting 37 homolog D (S. cerevisiae)
UniProt Protein Function:
VPS37D: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. VPS37D is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the VPS37 family.Chromosomal Location of Human Ortholog: 7q11.23Cellular Component: endosome membraneBiological Process: autophagy; endosome transport; viral infectious cycle
