The VPS41 Polyclonal Antibody (PAC017434) is a valuable tool for researchers studying VPS41, a protein involved in intracellular trafficking and membrane fusion processes. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples and has been validated for use in Western blot applications.VPS41 is a key component of the HOPS complex, which plays a crucial role in lysosomal biogenesis and endosome-lysosome fusion. Dysregulation of VPS41 has been implicated in various diseases, including lysosomal storage disorders and neurological conditions.
By targeting VPS41 with this antibody, researchers can investigate its function and its role in disease pathogenesis.This antibody enables the detection and analysis of VPS41 in different cell types, making it a versatile tool for studies in cell biology, molecular biology, and biomedicine. By understanding the mechanisms by which VPS41 functions, researchers can gain insights into potential therapeutic strategies for treating disorders associated with dysregulated intracellular trafficking pathways.
Antibody Name:
VPS41 Antibody (PACO17434)
Antibody SKU:
PACO17434
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human VPS41
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17434(VPS41 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17434(VPS41 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known.
Synonyms:
vacuolar protein sorting 41 homolog (S. cerevisiae)
UniProt Protein Function:
VPS41: Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating system; VesicleChromosomal Location of Human Ortholog: 7p14-p13Cellular Component: clathrin-coated vesicle; endosome membrane; late endosome membrane; lysosomal membraneMolecular Function: GTPase binding; identical protein binding; protein bindingBiological Process: endosomal vesicle fusion; endosome to lysosome transport; protein targeting to vacuole; vacuole fusion, non-autophagic
UniProt Protein Details:
NCBI Summary:
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]
