The VPS52 Polyclonal Antibody (PAC013198) is a valuable tool for researchers studying VPS52, a protein involved in intracellular trafficking and vesicle formation. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is suitable for Western blot applications. By targeting the VPS52 protein, this antibody allows for the detection and analysis of VPS52 in various cell types, making it ideal for investigations in cell biology and molecular biology.VPS52 plays a crucial role in maintaining cellular homeostasis by regulating the transport of proteins and lipids within the cell.
Dysregulation of VPS52 has been linked to various diseases, including neurodegenerative disorders and metabolic syndromes. Research on VPS52 is essential for understanding the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies targeting intracellular trafficking pathways.Overall, the VPS52 Polyclonal Antibody is a reliable tool for studying the function and localization of VPS52 in cellular processes, offering valuable insights into its role in health and disease.
vacuolar protein sorting 52 homolog (S. cerevisiae);VPS52;ARE1;DKFZp547I194;RP5-1033B10;SAC2;SACM2L;dJ1033B10.5 ;
UniProt Protein Function:
VPS52: May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Belongs to the VPS52 family.Chromosomal Location of Human Ortholog: 6p21.3Cellular Component: Golgi apparatus; membrane; perinuclear region of cytoplasm; recycling endosome; trans-Golgi network membraneMolecular Function: protein binding; syntaxin bindingBiological Process: endocytic recycling; lysosomal transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
