Description
VPS72 Antibody (PACO03103)
The VPS72 Polyclonal Antibody (PACO03103) is a valuable tool for researchers studying the VPS72 protein, which is involved in chromatin remodeling and transcriptional regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.VPS72 is a key component of the SWR1 chromatin remodeling complex, which plays a critical role in regulating gene expression by modulating nucleosome positioning.
Dysregulation of VPS72 has been linked to various diseases, including cancer and developmental disorders, highlighting its importance in cellular processes.By targeting the VPS72 protein, researchers can investigate its function in various cellular processes and pathways, providing insights into its role in gene regulation and potential therapeutic targets. The VPS72 Polyclonal Antibody is an essential tool for studies in epigenetics, gene expression, and chromatin dynamics.
| Antibody Name: | VPS72 Antibody |
| Antibody SKU: | PACO03103 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the Internal region of human VPS72. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | VPS72; TCFL1; YL1; Vacuolar protein sorting-associated protein 72 homolog; Protein YL-1; Transcription factor-like 1 |
| UniProt Protein Function: | VPS72: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. Belongs to the VPS72/YL1 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q21 Cellular Component: nucleoplasm; nucleus; protein complex Molecular Function:DNA binding; protein binding Biological Process: establishment and/or maintenance of chromatin architecture; histone exchange; negative regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q15906 |
| NCBI GenInfo Identifier: | 2499159 |
| NCBI Gene ID: | 6944 |
| NCBI Accession: | Q15906.1 |
| UniProt Secondary Accession: | Q15906,Q53GJ2, Q5U0R4, A6NLK9, A6PW55, |
| UniProt Related Accession: | Q15906 |
| Molecular Weight: | 41,848 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 72 homolog |
| NCBI Synonym Full Names: | vacuolar protein sorting 72 homolog |
| NCBI Official Symbol: | VPS72Â Â |
| NCBI Official Synonym Symbols: | YL1; CFL1; Swc2; YL-1; TCFL1Â Â |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 72 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 72 homolog |
| UniProt Synonym Protein Names: | Protein YL-1; Transcription factor-like 1 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS72Â Â |
| UniProt Entry Name: | VPS72_HUMAN |
