Description
VPS72 Antibody (PACO13201)
The VPS72 Polyclonal Antibody (PAC013201) is a crucial tool for researchers studying VPS72, a protein involved in chromatin remodeling and gene transcription regulation. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blotting applications. By binding to the VPS72 protein, this antibody allows for the detection and analysis of VPS72 in a variety of cell types, making it an essential asset for studies in molecular biology and cancer research.VPS72, a component of chromatin remodeling complexes, plays a vital role in controlling gene expression and maintaining genomic stability.
Its involvement in transcriptional regulation makes it a key player in cellular pathways linked to cancer development and progression. By studying the function of VPS72, researchers can gain valuable insights into the mechanisms underlying tumorigenesis and potentially identify new therapeutic targets for cancer treatment.Overall, the VPS72 Polyclonal Antibody offers a valuable tool for investigating the role of VPS72 in cellular processes and disease pathways, making it a valuable resource for researchers in the fields of molecular biology and oncology.
| Antibody Name: | VPS72 Antibody (PACO13201) |
| Antibody SKU: | PACO13201 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human VPS72 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | vacuolar protein sorting 72 homolog (S. cerevisiae);VPS72;CFL1;Swc2;TCFL1;YL-1;YL1 ; |
| UniProt Protein Function: | VPS72: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. Belongs to the VPS72/YL1 family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q21 Cellular Component: nucleoplasm; nucleus; protein complex Molecular Function:DNA binding; protein binding Biological Process: establishment and/or maintenance of chromatin architecture; histone exchange; negative regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q15906 |
| NCBI GenInfo Identifier: | 2499159 |
| NCBI Gene ID: | 6944 |
| NCBI Accession: | Q15906.1 |
| UniProt Secondary Accession: | Q15906,Q53GJ2, Q5U0R4, A6NLK9, A6PW55, |
| UniProt Related Accession: | Q15906 |
| Molecular Weight: | 41,848 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 72 homolog |
| NCBI Synonym Full Names: | vacuolar protein sorting 72 homolog |
| NCBI Official Symbol: | VPS72Â Â |
| NCBI Official Synonym Symbols: | YL1; CFL1; Swc2; YL-1; TCFL1Â Â |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 72 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 72 homolog |
| UniProt Synonym Protein Names: | Protein YL-1; Transcription factor-like 1 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS72Â Â |
| UniProt Entry Name: | VPS72_HUMAN |
