The WDR19 Antibody (PAC013228) is a high-quality polyclonal antibody designed for research involving WDR19, a protein involved in ciliogenesis and the regulation of cilia length. This antibody is produced in rabbits and is specifically reactive with human samples, making it a valuable tool for studying the role of WDR19 in cellular processes.WDR19 is a key player in the assembly and function of cilia, which are essential for various cellular processes such as signal transduction and cell motility. Dysregulation of ciliary function has been linked to a range of human diseases, including ciliopathies and cancer.
By targeting WDR19, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.This antibody has been validated for use in Western blot applications, allowing for the detection and analysis of WDR19 protein levels in different cell types. Its high specificity and sensitivity make it an ideal choice for studies in cell biology, developmental biology, and disease research. By utilizing this antibody, researchers can further explore the functions of WDR19 and its implications in human health and disease.
The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
