The WDR19 Antibody (PAC050834) is a valuable tool for researchers studying WDR19, a protein involved in ciliary function and intraflagellar transport. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to WDR19, this antibody enables accurate detection and analysis of the protein in various cell types, making it an essential component for studies in ciliopathy, developmental biology, and genetics.WDR19 is a key player in the assembly and function of cilia, hair-like structures on the surface of cells that play crucial roles in signal transduction and cellular movement.
Dysfunction of cilia has been linked to a wide range of human diseases, including ciliopathies, neurological disorders, and cancer. By investigating the role of WDR19 in ciliary processes, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new targets for therapeutic interventions.Overall, the WDR19 Antibody (PAC050834) is a valuable tool for researchers interested in understanding the functions of cilia and the implications of ciliary dysfunction in human health. Its high specificity and reliability make it an essential asset for studies in cell biology, genetics, and disease pathology.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO50834 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO50834 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human liver cancer using PACO50834 at dilution of 1:100.
Background:
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity). Associates with the BBSome complex to mediate ciliary transport (By similarity).
Synonyms:
WD repeat-containing protein 19 (Intraflagellar transport 144 homolog), WDR19, IFT144 KIAA1638
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the WD (tryptophan-aspartic acid) repeat family, which is a large family of structurally-related proteins known to participate in a wide range of cellular processes. Each WD repeat typically contains about 40 amino acids that are usually bracketed by glycine-histidine and tryptophan-aspartic acid (WD) dipeptides. This protein contains six WD repeats, three transmembrane domains, and a clathrin heavy-chain repeat. Mutations in this gene have been described in individuals with a wide range of disorders affecting function of the cilium. These disorders are known as ciliopathies, and include Jeune syndrome, Sensenbrenner syndromes, Senior-Loken syndrome, combined or isolated nephronophthisis (NPHP), and retinitis pigmentosa (RP). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
