The WEE2 Polyclonal Antibody (PAC013751) is a valuable tool for researchers studying WEE2, a key regulator of cell cycle progression. This antibody has been raised in rabbits and is highly specific for human samples, making it ideal for use in Western blot applications. By targeting the WEE2 protein, this antibody allows for the detection and analysis of WEE2 expression in various cell types, providing important insights for studies in reproductive biology and cancer research.WEE2 is a critical player in the regulation of the cell cycle, particularly in the control of meiosis and mitosis.
Dysregulation of WEE2 has been linked to various reproductive disorders and cancer progression, highlighting its potential as a therapeutic target. By gaining a deeper understanding of WEE2 activity, researchers can uncover new strategies for treating infertility and developing targeted therapies for cancer.Overall, the WEE2 Polyclonal Antibody is a valuable tool for researchers seeking to explore the functions of WEE2 in cellular processes and disease development. Its high specificity and reliability make it a trusted reagent for advancing our understanding of WEE2 biology.
WEE1B: a protein kinase of the WEE family expressed only in oocytes. Downregulation by RNAi causes a leaky meiotic arrest. The inhibitory effects of the kinase are enhanced when Ser15 is phosphorylated. Appears to be a key MPF inhibitory kinase in mouse oocytes and is required for maintaining meiotic arrest.Protein type: Protein kinase, Other; EC 2.7.10.2; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; WEE family; WEE1 subfamilyChromosomal Location of Human Ortholog: 7q32Cellular Component: nucleoplasm; cytoplasmMolecular Function: protein serine/threonine kinase activity; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; ATP bindingBiological Process: mitosis; peptidyl-tyrosine phosphorylation; female pronucleus formation; negative regulation of cyclin-dependent protein kinase activity; female meiosis
