Description
WNK1 Antibody (PACO20883)
The WNK1 Polyclonal Antibody (PAC020883) is a valuable tool for researchers studying WNK1, a serine/threonine kinase protein involved in various cellular processes, including regulation of ion transport and blood pressure. This antibody is produced in rabbits and is highly specific for detecting WNK1 protein in human samples. Validated for use in Western blot applications, the antibody binds to WNK1, allowing for precise detection and analysis in different cell types.WNK1 is a key player in the regulation of ion channels and transporters, making it a crucial target for understanding diseases related to electrolyte imbalance and hypertension.
Research on WNK1 can provide insights into the mechanisms underlying these conditions and facilitate the development of targeted therapies. The WNK1 Polyclonal Antibody is an essential tool for investigating the role of WNK1 in physiological and pathological processes, making it a valuable asset in biomedical research.
| Antibody Name: | WNK1 Antibody (PACO20883) |
| Antibody SKU: | PACO20883 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human WNK1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20883(WNK1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20883(WNK1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20883(WNK1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined. |
| Synonyms: | WNK lysine deficient protein kinase 1 |
| UniProt Protein Function: | WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic |
| NCBI Summary: | This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010] |
| UniProt Code: | Q9H4A3 |
| NCBI GenInfo Identifier: | 296453029 |
| NCBI Gene ID: | 65125 |
| NCBI Accession: | Q9H4A3.2 |
| UniProt Secondary Accession: | Q9H4A3,O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673 A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3, |
| UniProt Related Accession: | Q9H4A3 |
| Molecular Weight: | 2382 |
| NCBI Full Name: | Serine/threonine-protein kinase WNK1 |
| NCBI Synonym Full Names: | WNK lysine deficient protein kinase 1 |
| NCBI Official Symbol: | WNK1Â Â |
| NCBI Official Synonym Symbols: | KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167Â Â |
| NCBI Protein Information: | serine/threonine-protein kinase WNK1; erythrocyte 65 kDa protein; protein kinase with no lysine 1; prostate-derived sterile 20-like kinase; WNK lysine deficient protein kinase 1 isoform; protein phosphatase 1, regulatory subunit 167 |
| UniProt Protein Name: | Serine/threonine-protein kinase WNK1 |
| UniProt Synonym Protein Names: | Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | WNK1Â Â |
| UniProt Entry Name: | WNK1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
