The ZBTB20 Polyclonal Antibody (CAB7970) is a vital tool for researchers studying the ZBTB20 protein, which plays a key role in various cellular processes, including transcriptional regulation and cell proliferation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot experiments. By binding to the ZBTB20 protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it an excellent choice for studies in molecular biology and cancer research.
ZBTB20, also known as Zinc finger and BTB domain-containing protein 20, is a transcriptional repressor that regulates the expression of genes involved in cell differentiation and development. Its involvement in these crucial processes makes it a promising target for research into diseases such as cancer, developmental disorders, and neurodegenerative conditions. Understanding the function of ZBTB20 is essential for uncovering its potential as a therapeutic target or diagnostic marker in various pathologies.
Product Name:
ZBTB20 Rabbit Polyclonal Antibody
SKU:
CAB7970
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human ZBTB20 (NP_056457.3).
This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
26137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ZBTB20 antibody (CAB7970) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
