The ZC3H13 Polyclonal Antibody (PACO22692) is a valuable tool for researchers studying ZC3H13, a protein involved in mRNA processing and RNA metabolism. This antibody is produced in rabbits and has been shown to have high reactivity with human samples, making it suitable for use in Western blot applications. By specifically binding to the ZC3H13 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential reagent for studies in molecular biology and RNA biology.ZC3H13 plays a crucial role in regulating gene expression and mRNA stability, making it a key player in RNA processing pathways.
Its involvement in RNA metabolism suggests that it may be implicated in various diseases, making it a promising target for research in areas such as cancer, genetic disorders, and neurodegenerative diseases. By investigating the function of ZC3H13, researchers can uncover new insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for intervention.
Antibody Name:
ZC3H13 Antibody (PACO22692)
Antibody SKU:
PACO22692
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human ZC3H13.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells, A549 cells and Jurkat cells, using ZC3H13 antibody.
Background:
2 isoforms of the human protein are produced by alternative splicing.
Synonyms:
ZC313;
UniProt Protein Function:
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) ().
