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ZFP36L2 Antibody (PACO01632)

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SKU:
PACO01632
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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ZFP36L2 Antibody (PACO01632)

The ZFP36L2 Antibody (PACO01632) is a crucial tool for researchers studying the zinc finger protein ZFP36L2, which plays a key role in regulating gene expression and mRNA stability. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.ZFP36L2 is known for its involvement in controlling inflammatory responses and cell proliferation, making it a target of interest in immunology, cancer research, and developmental biology. By targeting the ZFP36L2 protein, this antibody facilitates the detection and analysis of ZFP36L2 in various cell types, providing valuable insights into its function and potential therapeutic applications.

With its high reactivity and specificity, the ZFP36L2 Antibody (PACO01632) is a valuable tool for researchers seeking to unravel the complex regulatory mechanisms of gene expression and mRNA stability mediated by ZFP36L2. Its use in studies on immune regulation, cancer biology, and developmental processes can lead to a better understanding of disease mechanisms and potential therapeutic targets.

Antibody Name:ZFP36L2 Antibody
Antibody SKU:PACO01632
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human TIS11D.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ZFP36L2; BRF2; ERF2; RNF162C; TIS11D; Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D
UniProt Protein Function:ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 2p22.3-p21

Cellular Component: cytoplasm; nucleus

Molecular Function:AU-rich element binding; transcription factor activity

Biological Process: cell proliferation; hemopoiesis; mRNA catabolic process; somatic stem cell division; somatic stem cell maintenance

NCBI Summary:This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
UniProt Code:P47974
NCBI GenInfo Identifier:146291085
NCBI Gene ID:678
NCBI Accession:P47974.3
UniProt Secondary Accession:P47974,Q53TB4, Q9BSJ3,
UniProt Related Accession:P47974
Molecular Weight:51,063 Da
NCBI Full Name:Zinc finger protein 36, C3H1 type-like 2
NCBI Synonym Full Names:ZFP36 ring finger protein like 2
NCBI Official Symbol:ZFP36L2  
NCBI Official Synonym Symbols:BRF2; ERF2; ERF-2; TIS11D; RNF162C  
NCBI Protein Information:zinc finger protein 36, C3H1 type-like 2
UniProt Protein Name:Zinc finger protein 36, C3H1 type-like 2
UniProt Synonym Protein Names:Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D
Protein Family:mRNA decay activator protein
UniProt Gene Name:ZFP36L2  
UniProt Entry Name:TISD_HUMAN

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