The ZMYND10 Polyclonal Antibody (PAC043808) is specifically designed for research involving ZMYND10, a zinc finger protein that plays a crucial role in gene regulation and chromatin remodeling. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.ZMYND10 is known to interact with various proteins involved in transcriptional regulation and DNA repair, making it a key player in cellular processes such as cell proliferation and differentiation.
Research has shown that dysregulation of ZMYND10 is linked to various diseases, including cancer and neurodevelopmental disorders.By using the ZMYND10 Polyclonal Antibody, researchers can study the expression and localization of ZMYND10 in different cell types and tissues, providing valuable insights into its function and potential role in disease pathogenesis. This antibody is a valuable tool for investigators in the fields of molecular biology, cancer research, and epigenetics.
Recombinant Human Zinc finger MYND domain-containing protein 10 protein (201-440AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot. All lanes: ZMYND10 antibody at 8µg/ml. Lane 1: A549 whole cell lysate. Lane 2: Mouse kidney tissue. Lane 3: Mouse skeletal muscle tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 51, 50 kDa. Observed band size: 51 kDa.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO43808 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO43808 at dilution of 1:100.
Background:
Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins.
Synonyms:
Zinc finger MYND domain-containing protein 10 (Protein BLu), ZMYND10, BLU
UniProt Protein Function:
ZMYND10: 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytoplasmMolecular Function: protein bindingDisease: Ciliary Dyskinesia, Primary, 22
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
